PERFLUOROOCTYL BROMIDE NANOEMULSIONS HOLDING MNO2 NANOPARTICLES WITH DUAL-MODALITY IMAGING AND GLUTATHIONE DEPLETION ENHANCED HIFU-ELICITING TUMOR IMMUNOGENIC CELL DEATH

Tumor-targeted immunotherapy is a remarkable breakthrough, offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity.However, existing platforms suffer from low efficacy, inability to induce strong immunogenic cell death (ICD), and restrained capacity of transforming immune-deserted tumors into im

Nephronophthisis (NPH) is an autosomal recessive ciliopathy and a major cause of end-stage renal disease in children.The main forms, juvenile and adult NPH, are characterized by tubulointerstitial fibrosis whereas the infantile form is more severe and characterized by cysts.NPH is caused by mutations in over 20 different genes, most of which encode

This case series describes transoral penetrating or contusive medullocervical injury by a wooden chopstick in three young cats presenting with acute tetraparesis.CT revealed that remnant fragments of a wooden chopstick penetrated the atlantooccipital SOAP space in cases 1 and 2.The remnant fragments were visualized clearly on CT under the bone wind

BACKGROUND:A number of studies have revealed a link between chronic periodontitis and cardiovascular disease in obese patients.However, there is little information about the influence of periodontitis-associated bacteria, Porphyromonas gingivalis (Pg), on pathogenesis of atherosclerosis in obesity.METHODS:In vivo experiment: C57BL/6J mice were fed